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  • Trialists Grapple with How to Outsmart TREM2 | ALZFORUM
    Series - AD PD™ 2025: Advances in Science Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to Harness AI for Alzheimer’s Research Part 3 of 15: Moving Target: New Biology Casts TREM2 as a Shifty Mark Part 4 of 15: TREM2: A Chill Pill for Neurons? Part 5 of 15: Trialists Grapple with How to Outsmart
  • TREM2: A Chill Pill for Neurons? | ALZFORUM
    TREM2 created quite the buzz at this year’s AD PD meeting, held April 1-5 in Vienna In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase trials of a fresh batch of agonists Juxtaposing this were presentations that unveiled a new modus operandi for
  • TREM2-IPD | ALZFORUM
    Summary Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor found on microglia, where it modulates cell activity and survival In addition to membrane-associated TREM2, there are soluble forms of the protein—generated by protease cleavage of the extracellular domain or expression of alternative transcripts that lack a transmembrane domain
  • All Roads Lead to TREM2: Gearing Up to Target This Receptor
    Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease Findings presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to
  • VG-3927 | ALZFORUM
    In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic In October 2023, the first volunteer was treated in a Phase 1, placebo-controlled, single- and multiple-ascending-dose safety study being conducted in Miami
  • Is Transgelin-2 a ‘Receptor’ for Soluble TREM2? | ALZFORUM
    Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of intense investigation Now, researchers led by Zhentao Zhang, Renmin Hospital of Wuhan University, China, say the soluble ectodomain
  • Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
    TREM2 antibody sports transferrin receptor binding domain to ease entry into brain It activated microglia and boosted brain glucose metabolism The antibody is in a first Phase 1 trial
  • TREM2 H157Y - ALZFORUM
    The H157Y mutation reduced activation in response to phospholipid ligands in 2B4 T cells engineered to turn on GFP expression when TREM2 was engaged (Song et al , 2017) and also decreased phagocytosis of pHrodo-E Coli by HEK Flp-in cells expressing the variant (Schlepckow et al , 2017), compared with cells that expressed wild-type TREM2
  • Trem2 R47H KI (JAX) - ALZFORUM
    R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers Several murine Trem2 R47H knock-in lines have been created using CRISPR Cas9 gene editing, but early models, including Jackson Lab’s Trem2 R47H KI, were found to show decreased expression of
  • A tetravalent TREM2 agonistic antibody reduced amyloid . . . - ALZFORUM
    Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease Sci Transl Med 2022 Sep 7;14 (661):eabq0095 PubMed





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