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  • Senescent-like neutrophils shape angiogenic immunosuppressive niches in . . .
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis
  • 中山一院匡铭 陈志航等：肿瘤里挨饿的中性粒细胞，如何 . . .
    中山一院匡铭 陈志航等：肿瘤里"挨饿"的中性粒细胞，如何"叛变"推动肠癌肝转移？ Senescent-like neutrophils shape angiogenic immunosuppressive niches in colorectal cancer liver metastasis
  • Senescent-like neutrophils shape angiogenic immunosuppressive niches in . . .
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis
  • Cancer Discovery | 匡铭 陈志航 许丽霞团队揭示衰老中性粒 . . .
    近日，中山大学附属第一医院肝胆 胰 外科中心 匡铭 团队在 Cancer Discovery 上发表了一项题为 Senescent-like neutrophils shapeangiogenicimmunosuppressive niches in colorectal cancer liver metastasis 的研究。 该研究揭示了TANs在CRLM 中的分布和临床意义，发现了BHLHE40+TAN亚群通过塑造血管生成-免疫抑制生态位促进CRLM进展的重要作用，并证明了靶向BHLHE40+TAN亚群可以恢复抗肿瘤免疫，为研发治疗结直肠癌肝转移的药物提供了新的思路。
  • 附属第一医院匡铭团队揭示衰老中性粒细胞塑造血管形成-免疫 . . .
    在小鼠模型中，中性粒细胞特异性敲除 Bhlhe40可显著促进抗肿瘤免疫并抑制结直肠癌肝转移瘤生长。 该研究首次绘制了CRLM中TANs的转录图谱，揭示BHLHE40+衰老样TAN亚群通过塑造血管生成-免疫抑制生态位促进肿瘤进展的功能及机制，并提出靶向BHLHE40+中性粒细胞作为CRLM治疗的新思路。
  • NGDC - GSA for Human
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis
  • Cancer Discovery | 匡铭 陈志航 许丽霞团队揭示衰老中性粒 . . .
    研究目的:探究肿瘤相关中性粒细胞（TANs）在结直肠癌肝转移（CRLM）中的分布、功能及作用机制。 结论:该研究通过单细胞测序等技术，发现CRLM中富集中性粒细胞，并鉴定出一类BHLHE40+衰老样中性粒细胞亚群（TAN1）。 该亚群在葡萄糖剥夺条件下分化，通过分泌VEGFA促进血管生成，并通过CCL3L1-CCR1轴招募免疫抑制性巨噬细胞，共同塑造促进肿瘤进展的“血管生成-免疫抑制生态位”。 靶向BHLHE40+亚群可恢复抗肿瘤免疫并抑制肝转移，为CRLM的免疫治疗提供了新靶点。
  • Senescent-like neutrophils shape angiogenic immunosuppressive niches in . . .
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis
  • Senescent-like neutrophils shape angiogenic . . .
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis
  • Browse - BioProject - CNCB-NGDC
    Our analysis reveals that a terminally differentiated pro-tumor neutrophils subset (TAN1), characterized by a glycolysis signature and a senescent phenotype, is significantly enriched in liver metastasis and associated with poor prognosis





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